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Evidence is increasing that all addiction without exception is related to issues with the brain's reward center, specially the mesolimbic system. This the main problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both when they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you need to err along the side of caution and allow FDA do its job and demand some study be done in order that the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to earn money and that they would say almost anything to keep people on their own medications.

Researchers found that participants taking this drug for the year, dropped a few pounds within four weeks and have kept the load off through the 56 weeks with the study. Contrave is really a combination from the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which are made up of multiple active ingredient, which may make them far better and safer.

Combo-pilling could be the newest fad or better yet the newest to come under scrutiny and so it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that by right now there aren't long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug also can raise hypertension and heartbeat, and shouldn't be used in individuals with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure level and heart rate and must stop used in patients with uncontrolled high hypertension, as well as by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients which has a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients to the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.


The most common effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.
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